[HTML][HTML] Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2 …
HCA Drexler, M Vockel, C Polaschegg, M Frye… - Molecular & Cellular …, 2019 - ASBMB
Vascular endothelial protein tyrosine phosphatase (VE-PTP, PTPRB) is a receptor type
phosphatase that is crucial for the regulation of endothelial junctions and blood vessel
development. We and others have shown recently that VE-PTP regulates vascular integrity
by dephosphorylating substrates that are key players in endothelial junction stability, such
as the angiopoietin receptor TIE2, the endothelial adherens junction protein VE-cadherin
and the vascular endothelial growth factor receptor VEGFR2. Here, we have systematically …
phosphatase that is crucial for the regulation of endothelial junctions and blood vessel
development. We and others have shown recently that VE-PTP regulates vascular integrity
by dephosphorylating substrates that are key players in endothelial junction stability, such
as the angiopoietin receptor TIE2, the endothelial adherens junction protein VE-cadherin
and the vascular endothelial growth factor receptor VEGFR2. Here, we have systematically …
